Microbial glycosylation of cardamonin by Mucor spinosus / 药学学报
Yao Xue Xue Bao
; (12): 733-737, 2011.
Article
en En
| WPRIM
| ID: wpr-348892
Biblioteca responsable:
WPRO
ABSTRACT
Microbial transformation of cardamonin by Mucor spinosus (CGMCC 3.3450) in preparative scale resulted in the isolation of two new products. Their structures were elucidated unambiguously by ESI-MS, 1H NMR, 13C NMR and 2D NMR spectra analyses as 4-O-beta-D-glucopyranosyl-6-hydroxy-2-methoxychalcone (1, 4-GluC) and 6-O-beta-D-glucopyranosyl-4-hydroxy-2-methoxychalcone (2, 6-GluC), respectively. The time-course of biotransformation by M. spinosus showed that both 4-GluC and 6-GluC appeared on the 2nd day. The optimal biotransformation temperature was 28 degrees C, the optimal biotransformation time was 72 h and the optimal concentration for cardamonin was 40 mg x mL(-1). This is the first time for successful microbial glycosylation of cardamonin in present research.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Glicosilación
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Biotransformación
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Espectroscopía de Resonancia Magnética
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Estructura Molecular
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Química
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Espectrometría de Masa por Ionización de Electrospray
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Chalconas
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Glucósidos
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Metabolismo
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Mucor
Idioma:
En
Revista:
Yao Xue Xue Bao
Año:
2011
Tipo del documento:
Article