Clinicopathologic analysis of spindle cell rhabdomyosarcoma: report of 8 cases / 中华肿瘤杂志
Zhonghua zhong liu za zhi
; (12): 141-143, 2008.
Article
en Zh
| WPRIM
| ID: wpr-348149
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathological features of spindle cell rhabdomyosarcoma (SCRMS) in order to differentiate it from other myosarcomas.</p><p><b>METHODS</b>The clinical features, morphologic and immunohistochemical phenotypes of 8 SCRMSs were analyzed.</p><p><b>RESULTS</b>SCRMS cells were found to be arranged in a fascicular or storiform pattern, in which a number of enlarged plump or polygonal shaped rhabdomyoblasts containing abundant eosinophilic cytoplasm with eccentrically placed enlarged hyperchromatic nuclei were mixed. Immunohistochemical staining results showed that vimentin, MyoD1, desmin, actin, myoglobin were positive in tumor cells, but S-100, plap, AE1/AE3, CK, CD117 negative. The follow-up data showed that four cases had died of the recurrent disease, one still alive and the remain three patients lost follow-up.</p><p><b>CONCLUSION</b>Spindle cell rhabdomyosarcoma is a rare embryonal rhabdomyosarcoma which occurs in the childhood or adulthood with a poor prognosis, and is frequently presented as a painless mass most frequently involveing the head and neck or cervical area or para-testis site. A combination of MyoD1, desmin and myoglobin immunohistochemical staining is helpful in differential diagnosis.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Neoplasias de los Tejidos Blandos
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Cirugía General
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Estudios Retrospectivos
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Estudios de Seguimiento
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Rabdomiosarcoma Embrionario
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Proteína MioD
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Terapia Combinada
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Desmina
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Diagnóstico Diferencial
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua zhong liu za zhi
Año:
2008
Tipo del documento:
Article