Misdiagnosis of 3 cases lymphoma due to misjudgement of immunohistochemistry / 中华血液学杂志
Chinese Journal of Hematology
; (12): 20-24, 2012.
Article
en Zh
| WPRIM
| ID: wpr-345953
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To recognize the importance of analyzing the result of immunohistochemical staining correctly.</p><p><b>METHOD</b>Review of the three misdiagnosed cases lymphoma and exploring the causes of misdiagnosis through reviewing their clinics, histopathology and immunohistochemistry.</p><p><b>RESULTS</b>Case 1 of lymphocyte rich classical Hodgkin's lymphoma (LRCHL) was misdiagnosed as follicular lymphoma (FL) initially, the RS cells were overlooked morphologically and wrongly determined BCL-2 and CD20-positive cells as tumor cells immunohistochemically; also once misdiagnosed as nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) because the CD20-negative RS misjudged cells as the positives. Case 2 of AML tumor cells expressed TdT, CD7 and CD43 unspecifically, which misdiagnosed as T-cell lymphoblastic lymphoma (T-LBL). Case 3 of type B1 thymoma was misdiagnosed as T-LBL, because CK wasn't expressed satisfactorily resulting in neglecting neoplastic epithelial cells, and lymphocytes in the background were TdT and CD99-positive.</p><p><b>CONCLUSION</b>The diagnosis of lymphoma should be based on morphology, immunohistochemistry, clinics, and genetics. Moreover, the correct judgment of immunohistochemical staining is essential to make right diagnosis.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Inmunohistoquímica
/
Diagnóstico
/
Errores Diagnósticos
/
Linfoma
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Hematology
Año:
2012
Tipo del documento:
Article