Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice
Nutrition Research and Practice
; : 472-479, 2015.
Article
en En
| WPRIM
| ID: wpr-34493
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/OBJECTIVES: The goal of this study was to examine the effect of Sargassum coreanum extract (SCE) on blood glucose concentration and insulin resistance in C57BL-KsJ-db/db mice. MATERIALS/METHODS: For 6 weeks, male C57BL/KsJ-db/db mice were administrated SCE (0.5%, w/w), and rosiglitazone (0.005%, w/w). RESULTS: A supplement of the SCE for 6 weeks induced a significant reduction in blood glucose and glycosylated hemoglobin concentrations, and it improved hyperinsulinemia compared to the diabetic control db/db mice. The glucokinase activity in the hepatic glucose metabolism increased in the SCE-supplemented db/db mice, while phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activities in the SCE-supplemented db/db mice were significantly lower than those in the diabetic control db/db mice. The homeostatic index of insulin resistance was lower in the SCE-supplemented db/db mice than in the diabetic control db/db mice. CONCLUSIONS: These results suggest that a supplement of the SCE lowers the blood glucose concentration by altering the hepatic glucose metabolic enzyme activities and improves insulin resistance.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fosfoenolpiruvato
/
Glucemia
/
Hemoglobina Glucada
/
Resistencia a la Insulina
/
Glucosa-6-Fosfatasa
/
Sargassum
/
Glucoquinasa
/
Glucosa
/
Hiperglucemia
/
Hiperinsulinismo
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Nutrition Research and Practice
Año:
2015
Tipo del documento:
Article