Intestinal absorption of daphnetin by rats single pass perfusion in situ / 药学学报
Acta Pharmaceutica Sinica
; (12): 922-926, 2009.
Article
en Zh
| WPRIM
| ID: wpr-344018
Biblioteca responsable:
WPRO
ABSTRACT
This study investigated the effects of concentration, intestinal section, pH and P-gp on the absorption of daphnetin. The absorptions of three concentrations (10, 20, 40 microg x mL(-1)) of daphnetin in different intestinal segments were studied with phenol red as the marker by in situ rats single pass perfusion model. The results showed that daphnetin was stable under pH 6.0 condition and little affected by metabolism enzyme. There was upgrade tendency between the Peff of duodenum, jejunum, ileum and colon in different concentration of daphnetin, and it has obvious difference between the high concentration and low concentration in jejunum and colon, which indicated that the absorption of daphnetin was passive diffusion and no difference in different segments of rat intestine. However, compared with colon, the absorption of small intestine was better significantly (P < 0.05). Daphnetin may be not a substrate of P-gp as verapamil had not significantly affected the absorption of daphnetin in different intestinal segments of rats.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Perfusión
/
Permeabilidad
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Umbeliferonas
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Farmacocinética
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Ratas Sprague-Dawley
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Miembro 1 de la Subfamilia B de Casetes de Unión a ATP
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Concentración de Iones de Hidrógeno
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Absorción Intestinal
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Metabolismo
Límite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Article