Recent advances in the production of heterologous proteins in filamentous fungi / 生物工程学报
Chinese Journal of Biotechnology
; (12): 531-540, 2008.
Article
en Zh
| WPRIM
| ID: wpr-342875
Biblioteca responsable:
WPRO
ABSTRACT
Filamentous fungi can secrete large amounts of proteins, glycosylate proteins and grow faster than plant, insect or mammalian cells. With the advances in fungal molecular genetics, strain improvement, and especially fungal genomics, filamentous fungi are developed as microbial cell factories for the production of heterologous proteins. This review focuses on recent developments of filamentous fungi as production hosts, such as protein quality control mechanisms, the secretion pathways, protein modification, strain stability, and most importantly the application of functional genomics in protein expression. At the same time, the strategies for improving heterologous protein production were also discussed in details.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fisiología
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Biotecnología
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Proteínas Recombinantes
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Ingeniería Genética
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Procesamiento Proteico-Postraduccional
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Clonación Molecular
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Fermentación
/
Hongos
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Genética
/
Metabolismo
Idioma:
Zh
Revista:
Chinese Journal of Biotechnology
Año:
2008
Tipo del documento:
Article