Association between the polymorphisms of cluster of differentiation 14 gene promoters and the susceptibility of multiple organ dysfunction syndrome after severe chest trauma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 362-366, 2011.
Article
en Zh
| WPRIM
| ID: wpr-341402
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the polymorphisms of cluster of differentiation 14(CD14)gene promoters and explore whether such polymorphisms are associated with the susceptibility to multiple organ dysfunction syndrome(MODS) in Chongqing population.</p><p><b>METHODS</b>The single nucleotide polymorphisms of the promoter region of CD14 gene at position -1145 and -159 were detected using polymerase chain reaction-restriction fragment length polymorphism method in 106 patients with severe chest trauma, among whom 47 were with MODS.</p><p><b>RESULTS</b>Trauma patients carrying G allele tended to have a higher risk of MODS than those carrying A allele at position-1145, the MODS scores in trauma patients carrying G allele were significantly higher than those carrying A allele (P=0.217 for dominant effect and P=0.037 for recessive effect), and the MODS scores in trauma patients carrying T allele were significantly higher than those carrying C allele at position -159 (P=0.048 for dominant effect and P=0.198 for recessive effect). The genotypes of CD14 gene at positions -1145 and -159 were significantly correlated with the MODS scores (P=0.043,P=0.046). Compare with single-point mutation, simultaneous two-point mutation had significantly higher risk of MODS (Pü0.01), while the difference of MODS scores showed no statistical significance (P=0.239).</p><p><b>CONCLUSION</b>The polymorphisms of CD14 gene promoters are associated with MODS after severe chest trauma in Chongqing population.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Polimorfismo Genético
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Traumatismos Torácicos
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Polimorfismo de Longitud del Fragmento de Restricción
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Regiones Promotoras Genéticas
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Receptores de Lipopolisacáridos
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Genética
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Genotipo
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Insuficiencia Multiorgánica
Límite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Año:
2011
Tipo del documento:
Article