Association between interleukin-1β C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study / 中国当代儿科杂志
Zhongguo dangdai erke zazhi
; Zhongguo dangdai erke zazhi;(12): 1123-1129, 2016.
Article
en Zh
| WPRIM
| ID: wpr-340554
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between interleukin-1β (IL-1β) C+3953T and genetic susceptibility to spontaneous preterm birth (SPTB).</p><p><b>METHODS</b>In this case-control study, 753 SPTB neonates were enrolled in the case group and 681 full-term neonates were enrolled in the control group. The latest Sequenom MassARRAY®SNP detection technique was used for the typing of single nucleotide polymorphisms (SNP) of IL-1β C+3953T.</p><p><b>RESULTS</b>Compared with those carrying CC genotype of IL-1β C+3953T, the neonates who carried at least one T allele (CT+TT genotype) had significantly increased risks of SPTB, SPTB complicated by premature rupture of membranes, and mild preterm birth.</p><p><b>CONCLUSIONS</b>In the Chinese population, IL-1β C+3953T has significant genetic association with an increased risk of SPTB. The identification of this SNP helps to prevent SPTB and clarify the causes and pathogenesis of SPTB.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Estudios de Casos y Controles
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Nacimiento Prematuro
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Interleucina-1beta
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Genética
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
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Newborn
Idioma:
Zh
Revista:
Zhongguo dangdai erke zazhi
Año:
2016
Tipo del documento:
Article