Expression of Beclin1 in primary hepatocellular carcinoma / 南方医科大学学报
Journal of Southern Medical University
; (12): 151-153, 2009.
Article
en Zh
| WPRIM
| ID: wpr-339042
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To detect Beclin1 expression and explore its clinical significance in primary hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>Beclin1 expressions in 10 normal hepatic tissues, 30 hepatitis liver, 30 cirrhotic liver and 50 HCC tissues were detected by immunohistochemical staining.</p><p><b>RESULTS</b>The positivity rates of Beclin1 expression in the HCC, cirrhotic liver, hepatitis liver and normal liver tissues were 78.00% (39/50), 26.67% (8/30), 53.33% (16/30), and 10.00% (1/10), respectively, showing significant differences between them (chi(2)=28.31, P<0.05). Beclin1 expression was significantly higher in HCC tissues than in the cirrhotic, hepatitis and normal liver tissues (chi(2)=20.39, 5.31, and 14.41, respectively, P<0.05), and hepatitis tissues showed significantly higher Beclin1 expression than hepatic cirrhosis tissues and normal hepatic tissues (chi(2)=4.44 and 4.12, respectively, P<0.05).</p><p><b>CONCLUSION</b>The abnormal expression of Beclin1 is closely associated with the pathogenesis and development of primary hepatocellular carcinoma, and may play an important role in this process.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Inmunohistoquímica
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Carcinoma Hepatocelular
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Proteínas Reguladoras de la Apoptosis
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Beclina-1
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Genética
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Neoplasias Hepáticas
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Proteínas de la Membrana
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Metabolismo
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2009
Tipo del documento:
Article