Effect of genetic polymorphism of MTNR1A gene on adolescent idiopathic scoliosis / 中华外科杂志
Zhonghua Wai Ke Za Zhi
; (12): 1264-1266, 2007.
Article
en Zh
| WPRIM
| ID: wpr-338177
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the MTNR1A gene promotor polymorphism (rs2119882) are associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS).</p><p><b>METHODS</b>226 AIS patients and 277 normal controls were recruited. The maximum Cobb angles were recorded in AIS patients. PCR-RFLP was used for the genotyping.</p><p><b>RESULTS</b>The genotype and allele frequency distribution were comparable between AIS and normal control, the mean maximum Cobb angle of different genotypes of rs2119882 were similar with each other among AIS patients.</p><p><b>CONCLUSION</b>The MTNR1A gene promoter polymorphism was neither associated with the occurrence nor the curve severity of AIS.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Polimorfismo Genético
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Escoliosis
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Polimorfismo de Longitud del Fragmento de Restricción
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Reacción en Cadena de la Polimerasa
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Predisposición Genética a la Enfermedad
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Receptor de Melatonina MT1
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Frecuencia de los Genes
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Genética
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Genotipo
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua Wai Ke Za Zhi
Año:
2007
Tipo del documento:
Article