Toxical research of Kudiezi injection in safety re-evaluation / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 2828-2830, 2012.
Article
en Zh
| WPRIM
| ID: wpr-338005
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the toxic effect on mouse administrated Kudiezi injection multy times a day, and on rats repeat administrated for many days.</p><p><b>METHOD</b>Mouse tail intravenous injection of Kudiezi, 0.04 mL x g(-1), 3 times a day, rats tail intravenous injection of Kudiezi, 20, 10, 4 mL x kg(-1), once a day, for 6 weeks.</p><p><b>RESULT</b>There is no abnormal to the mouses administrated many times a day. The rats administrated large doses of drug for many days have certain effects on hematology, blood biochemistry. Some animals appear liver, kidney lesions mild, injection local appear haemorrhage, edema and inflammatory reaction.</p><p><b>CONCLUSION</b>The mouse which was intravenous injection in the dose of 180 times Kudiezi injection as much as people used, revealed no toxicity reaction. Repeated large-dose administration, rats caused by lesions of the main target organs may be for kidney, liver. But the recovery result on liver, kidney toxicity was reversible, no delayed toxicity. At the same time, large doses of long-term administration of local have a certain irritation. Tips the medication should be under the guidance of doctors, and pay attention to replace the injection site. This research will provide safety basis for the clinical use of Kudiezi injection.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Medicamentos Herbarios Chinos
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Ratas Wistar
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Modelos Animales
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Relación Dosis-Respuesta a Droga
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Quimioterapia
Tipo de estudio:
Guideline
Límite:
Animals
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2012
Tipo del documento:
Article