Selection of donor in mismatched hematopoietic stem cell transplantation by CREG, residue match and HLA three-dimensional structure / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 553-556, 2002.
Article
en Zh
| WPRIM
| ID: wpr-337675
Biblioteca responsable:
WPRO
ABSTRACT
After search at hematopoietic stem cell banks for transplant donors, there may be several donors matched with given standards. To determine the most appropriate donor for a specific patient, the potential donors were analyzed and compared by three methods. The first is cross-reactive group (CREG) antigens, which defined as the public antigens that shared specific serological reaction patterns. The second is residue match theory, which concerned the three residues oriented upward toward the T-cell receptor. The third is comparing HLA three-dimensional structure models. The results of the three methods were not completely accorded in our case. However, some less matched donors could be excluded from the candidates and the range of selection was further reduced. It is concluded that combined application of three methods would contribute in selecting donor for hematopoietic stem cell transplantation in clinics.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Donantes de Tejidos
/
Prueba de Histocompatibilidad
/
Trasplante de Células Madre Hematopoyéticas
/
Reacciones Cruzadas
/
Alergia e Inmunología
/
Antígenos HLA
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2002
Tipo del documento:
Article