Effects of SiRNA-EGFR on the expression of hyaluronidase gene EGFR in human breast cancer cells / 南方医科大学学报
Journal of Southern Medical University
; (12): 1260-1263, 2010.
Article
en Zh
| WPRIM
| ID: wpr-336205
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of SiRNA-EGFR on the expression of hyaluronidase gene in human breast cancer cells.</p><p><b>METHODS</b>Reverse transcription-polymerse chain reaction was used to detect the changes in the expression of EGFR mRNA in human breast cancer cell lines MDA-MB-231, MDA-MB-435S, ZR-75 and ZR-75-30 after transfection by SiRNA-EGFR.</p><p><b>RESULTS</b>After transfection with SiRNA-EGFR, the expression levels of EGFR were significantly inhibited in MDA-MB-231, MDA-MB-435S, ZR-75 and ZR-75-30 cells (P<0.05).</p><p><b>CONCLUSION</b>Transfection by SiRNA-EGFR can inhibit the expression of EGFR mRNA in human breast cancer cells.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
/
Neoplasias de la Mama
/
ARN Mensajero
/
Transfección
/
ARN Interferente Pequeño
/
Interferencia de ARN
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Línea Celular Tumoral
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Receptores ErbB
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Genética
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Hialuronoglucosaminidasa
Límite:
Female
/
Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2010
Tipo del documento:
Article