Study on clinicopathologic parameters of malignant behavior in gastrointestinal stromal tumors / 中华病理学杂志
Zhonghua Bing Li Xue Za Zhi
; (12): 325-331, 2010.
Article
en Zh
| WPRIM
| ID: wpr-333274
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determinate the clinicopathologic parameters in predicting the malignant behavior of gastrointestinal stromal tumor (GIST).</p><p><b>METHODS</b>Eight hundred and forty cases of GIST were retrospectively reviewed. The tumors were classified as malignant if they met any of the following criteria: evidence of gross dissemination (including liver metastasis and/or peritoneal spread), evidence of microscopic dissemination (including lymph node metastasis, infiltration to vessels, fat tissue, nerves and/or mucosal tissue), or disease relapse. The remaining cases were provisionally classified as tumors of uncertain biologic behavior. A number of morphologic parameters were then evaluated under light microscopy and univariate and multivariate analyses were adopted for this study.</p><p><b>RESULTS</b>Histologic findings correlated with evidences of the following morphologic parameters were considered in accord with the criteria of the malignant behavior: mitotic count>or=10 per 50 high-power fields (P<0.01), muscle infiltration (P<0.01), coagulative necrosis (P<0.01), perivascular growth pattern (P=0.005) and remarkable nuclear atypia (P=0.014). Basing on the above criterion, 485 cases were re-classified as "malignant" and 355 cases "non-malignant". Follow-up data showed that the five-year disease-free survival and overall survival in the "non-malignant" group were 99.3% and 100% respectively, in contrast to 43.9% and 59.7% respectively in the "malignant" group (P<0.01).</p><p><b>CONCLUSIONS</b>The set of clinicopathologic parameters is useful in predicting the malignant behavior of GIST and prognosis.</p>
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1
Base de datos:
WPRIM
Asunto principal:
Patología
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Cavidad Peritoneal
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Tasa de Supervivencia
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Estudios Retrospectivos
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Estudios de Seguimiento
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Clasificación
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Medición de Riesgo
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Supervivencia sin Enfermedad
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Tumores del Estroma Gastrointestinal
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Neoplasias Hepáticas
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua Bing Li Xue Za Zhi
Año:
2010
Tipo del documento:
Article