The role of serum leptin in infants with wheezing after respiratory syncytial virus infected / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 38-40, 2009.
Article
en Zh
| WPRIM
| ID: wpr-332436
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the role of serum leptin in infants with wheezing after respiratory syncytial virus infected.</p><p><b>METHODS</b>43 infants infected with RSV were given blood samples to detect leptin concentration with radioimmunoassays (RIA) within 24 hours after admission into hospital, discharged and 12 weeks later. Then, they were followed up for 2 years. 10 healthy children of the same age served as controls.</p><p><b>RESULTS</b>41.9% infants developed asthma after infected with RSV. Compared to control group, the serum level of leptin in the asthma group and non-asthma group were significantly higher before treatment (t = 3.41 and 2.64 respectively, P < 0.05). When they were discharged, the serum level of leptin in the asthma group was significantly higher than that in non-asthma group and control group (t = 5.74 and 6.23, respectively, P < 0.05). 12 weeks later, the serum level of leptin in the asthma group was still significantly higher than that in non-asthma group and control group (t = 6.32 and 6.11, respectively, P < 0.05), but there were no difference between non-asthma group and control group (t = 0.81, P > 0.05).</p><p><b>CONCLUSION</b>The serum level of leptin in infants with asthma after RSV infected was higher than that in healthy and non-asthma children. Persistent higher level of leptin may play an important role in infants with asthma after RSV infected.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fisiología
/
Virus Sincitiales Respiratorios
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Asma
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Virología
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Sangre
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Estudios de Casos y Controles
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Ruidos Respiratorios
/
Estudios de Seguimiento
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Infecciones por Virus Sincitial Respiratorio
/
Leptina
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Child, preschool
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Female
/
Humans
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Infant
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Male
Idioma:
Zh
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2009
Tipo del documento:
Article