Plasma levels of vWF and NO in patients with metabolic syndrome and their relationship with metabolic disorders / 浙江大学学报·医学版
Zhejiang Daxue xuebao. Yixue ban
; (6): 315-318, 2006.
Article
en Zh
| WPRIM
| ID: wpr-332152
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To measure the plasma levels of von Willebrand factor (vWF) and nitric oxide (NO) in patients with metabolic disorders and to study their relationships with the disease.</p><p><b>METHODS</b>The plasma levels of vWF and NO were determined in patients with metabolic syndrome (MS group, n=36), patients with 1 - 2 metabolic disorders (MD group, n=43) and normal subjects (control group, n=30).</p><p><b>RESULT</b>The plasma vWF level was higher in MS group than that in MD group (P <0.05) and in control group (P <0.001); the vWF level in MD group was higher than that in control group (P <0.05). The NO level was lower in MS group and in MD group than that in control group (both P<0.05), while the difference between MS and MD groups was not statistically significant (P >0.05). Multiple stepwise regression showed that vWF level was correlated with systolic BP (SBP), diastolic BP(DBP) and pulse BP; that NO level was correlated with BMI, SBP and TG.</p><p><b>CONCLUSION</b>Multiple metabolic disorders of metabolic syndrome may injure endothelial cells, and the degree of endothelial cell injury seems to be correlated with the BMI, SBP, DBP, pulse BP and TG.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Pulso Arterial
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Sangre
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Presión Sanguínea
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Factor de von Willebrand
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Endotelio Vascular
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Índice de Masa Corporal
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Síndrome Metabólico
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Metabolismo
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Óxido Nítrico
Límite:
Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhejiang Daxue xuebao. Yixue ban
Año:
2006
Tipo del documento:
Article