Role of endoplasmic reticulum-plasma membrane junctions in intracellular calcium homeostasis and cardiovascular disease / 生理学报
Acta Physiologica Sinica
; (6): 517-524, 2016.
Article
en Zh
| WPRIM
| ID: wpr-331634
Biblioteca responsable:
WPRO
ABSTRACT
Calcium overload is one of the important mechanisms of cardiovascular disease. Endoplasmic reticulum is an important organelle which regulates intracellular calcium homeostasis by uptake, storage and mobilization of calcium. So it plays a critical role in regulation of intracellular calcium homeostasis. Endoplasmic reticulum, which is widely distributed in cytoplasm, has a large number of membrane junction sites. Recent studies have reported that these junction sites are distributed on plasma membrane and organelle membranes (mitochondria, lysosomes, Golgi apparatus, etc.), separately. They could form complexes to regulate calcium transport. In this review, we briefly outlined the recent research progresses of endoplasmic reticulum-plasma membrane junctions in intracellular calcium homeostasis and cardiovascular disease, which may offer a new strategy for prevention and treatment of cardiovascular disease.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Enfermedades Cardiovasculares
/
Membrana Celular
/
Calcio
/
Retículo Endoplásmico
/
Homeostasis
Límite:
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Año:
2016
Tipo del documento:
Article