Natural history of small hepatocellular carcinoma: studied by MRI / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 222-225, 2005.
Article
en Zh
| WPRIM
| ID: wpr-331187
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study natural history of small hepatocellular carcinoma (sHCC) and value of MRI in this research.</p><p><b>METHODS</b>From 1999 to 2002, serial MR imagings were performed in 192 patients with cirrhosis no less than twice in order to detect sHCC focus. Characteristic MRI findings of focus were analysed. Diameters of focus (D) were measured. Tumorigenesis detected time (T) was counted; T and D were analysed by statistics and tumor volume doubling time (T(d)) was calculated.</p><p><b>RESULTS</b>Fifty-eight new tumor foci in 33 patients were found, including 31 foci in 23 patients developed on the basis of cirrhosis, with a 12.0% cumulative tumorigenic rate of three years. The tumorigenesis detected time (T) was 386.9 +/- 256.4 days and the maximum diameter (D) was 2.258 +/- 1.074 cm. T was statistical correlated with D(3) (P < 0.01) and regressive formulas were established: D(3) = -2.69 + 0.058T (P = 0.0007), D(3) = -72.13 + 16.04lnT (P = 0.0064). Tumor volume doubling time was 20 approximately 279 days (mean: 104 days).</p><p><b>CONCLUSION</b>The percentage of tumorigenesis is high in patients with cirrhosis. Regular MRI examinations are necessary to detect sHCC early. The optimal interval time is 3 approximately 6 months.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Imagen por Resonancia Magnética
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Estudios de Seguimiento
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Carcinoma Hepatocelular
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Diagnóstico
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Cirrosis Hepática
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Neoplasias Hepáticas
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Año:
2005
Tipo del documento:
Article