Correlation between ATP bioluminescence tumor chemosensitivity assay and clinical response in ovarian cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 296-298, 2005.
Article
en Zh
| WPRIM
| ID: wpr-331165
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the correlation between results of ATP bioluminescence tumor chemosensitivity assay (ATP-TCA) of human ovarian cancer specimens in vitro and clinical chemo-therapeutic responses of patients.</p><p><b>METHODS</b>Thirty-four freshly taken ovarian cancer specimens (28 cases) and ascites (6 cases) and 9 chemotherapeutic drugs were tested in vitro for cancer chemosensitivity by ATP-TCA.</p><p><b>RESULTS</b>Among the 34 ovarian cancer cases, the efficacy of ATP-TCA is 94.0%, the sensitivity, the specificity, the positive and negative predicting values, and an overall predicting value in vitro and vivo were 90.0%, 91.7%, 94.7%, 84.6% and 90.6%, respectively.</p><p><b>CONCLUSION</b>The results of ATP-TCA assay are correlated well with clinical treatment responses. The assay may be an important and useful method for individual-based chemotherapy of cancers.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neoplasias Ováricas
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Patología
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Farmacología
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Ensayos de Selección de Medicamentos Antitumorales
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Carcinoma
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Protocolos de Quimioterapia Combinada Antineoplásica
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Adenosina Trifosfato
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Valor Predictivo de las Pruebas
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Sensibilidad y Especificidad
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Cisplatino
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Aged
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Female
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Año:
2005
Tipo del documento:
Article