Expression related to vascular endothelial growth factor C and induced nitride oxide synthesizase in lymph node micrometastasis of oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 445-459, 2004.
Article
en Zh
| WPRIM
| ID: wpr-330025
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of vascular endothelial growth factor C (VEGF-C) and induced nitride oxide synthesizase (iNOS) expression in lymph node micrometastasis of oral squamous cell carcinoma.</p><p><b>METHODS</b>Samples were obtained from 47 cases of oral squamous cell carcinoma and 15 cases with normal oral mucosa, VEGF-C and iNOS mRNA expression were detected by RT-PCR method. Lymph node micrometastasis of 10 normal lymph nodes and 355 lymph nodes from 47 cases of oral squamous cell carcinoma was detected with immunohistochemical reaction in cytokeratin antibody.</p><p><b>RESULTS</b>The percentages in tumors with higher expression were 57.4% for VEGF-C, 68.1% for iNOS (P < 0.05). They were significantly higher than that of normal groups. Significant positive relationship was found between VEGF-C and iNOS (P < 0.01). The positive rate of cytokeratin (CK) was 48.9%. Significant positive relationship was found between VEGF-C and CK, iNOS and CK (P < 0.01). The expression rates of CK in positive group of VEGF-C and iNOS were 63.0%, 65.6% respectively, and were significant higher than negative groups.</p><p><b>CONCLUSION</b>Expression of VEGF-C and iNOS in lymph node micrometastasis of oral squamous cell carcinoma is significant related.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Neoplasias de la Boca
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Carcinoma de Células Escamosas
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Factor C de Crecimiento Endotelial Vascular
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Óxido Nítrico Sintasa de Tipo II
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Micrometástasis de Neoplasia
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Queratinas
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Metástasis Linfática
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Metabolismo
Límite:
Humans
Idioma:
Zh
Revista:
West China Journal of Stomatology
Año:
2004
Tipo del documento:
Article