The associations of HLA-DQB1 gene with onset age and autoantibodies in type 1 diabetes / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 368-371, 2004.
Article
en Zh
| WPRIM
| ID: wpr-328875
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the associations of human leukocyte antigen (HLA) DQB1 gene with onset age and autoantibodies in type 1 diabetes mellitus(T1DM) in Chinese Han population in Sichuan area.</p><p><b>METHODS</b>Forty-six type 1 diabetic patients and 52 healthy control subjects were involved in this study. HLA-DQB1 typing was performed by polymerase chain reaction-sequence specific primer(PCR-SSP). Glutamic acid decarboxylase antibody (GADA) and islet cell antibody (ICA) were qualitatively analyzed by enzyme linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>The positive rate of DQB1*0201 was higher in T1DM than in controls (OR=18, P<0.005), but those of DQB1*0601, *0602 were higher in controls than in T1DM(OR=0.07, 0.31 respectively, both P<0.05).The positive rate of DQB1*0602 in type 1 diabetic patients with onset age>or=20 years was higher than that in the patients with onset age <20 years (P<0.05). GADA was more frequent in DQB1*0201(+) patients than in DQB1*0201 (-) patients (P<0.025).</p><p><b>CONCLUSION</b>The findings show that DQB1*0201 is susceptible to T1DM, whereas DQB1*0601, *0602 are protective in Chinese Han population in Sichuan area. DQB1*0602 may delay the onset of T1DM. The positive rate of DQB1*0201 correlates positively with that of GADA.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Autoanticuerpos
/
Ensayo de Inmunoadsorción Enzimática
/
Glicoproteínas de Membrana
/
Antígenos HLA-DQ
/
China
/
Reacción en Cadena de la Polimerasa
/
Epidemiología
/
Edad de Inicio
/
Predisposición Genética a la Enfermedad
/
Diabetes Mellitus Tipo 1
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2004
Tipo del documento:
Article