Study of trisomy 22 and inversion 16 in acute myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology
; (12): 11-14, 2007.
Article
en Zh
| WPRIM
| ID: wpr-328381
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the value of trisomy 22 ( +22) in the diagnosis of inv(16) acute myeloid leukemia (AML).</p><p><b>METHODS</b>Interphase fluorescence in situ hybridization (FISH) was performed in 18 AML patients with +22. The probe was two-color break apart probe for CBFbeta with SpectrumRed on the centromeric side and SpectrumGreen on the telomeric side. The FISH results were compared with that of R-banding conventional cytogenetics (CC). Multiplex FISH (M-FISH) was used to analyze the relationship of +22 and inv(16).</p><p><b>RESULTS</b>CC revealed inv(16) in none of the 18 AML, with +22, but FISH revealed inv (16) in 11 of them and del( 16) (q22) in one. As CC results, 9 of the 11 cases were sole +22, one complicated with trisomy 8, and one del(16) (q22). Four patients with +22 and inv(16) were analyzed by M-FISH and revealed +22 only.</p><p><b>CONCLUSION</b>+22 can be regarded as an important marker for the diagnosis of inv(16) AML.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Trisomía
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Cromosomas Humanos Par 16
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Cromosomas Humanos Par 22
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Leucemia Mieloide Aguda
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Hibridación Fluorescente in Situ
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Genética
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Inversión Cromosómica
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Hematology
Año:
2007
Tipo del documento:
Article