Study on molecular cytogenetic abnormalities in multiple myeloma / 中华血液学杂志
Chinese Journal of Hematology
; (12): 223-226, 2007.
Article
en Zh
| WPRIM
| ID: wpr-328351
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the molecular cytogenetic abnormalities in multiple myeloma (MM).</p><p><b>METHODS</b>Bone marrow plasma cells from 23 previously untreated MM patients were purified by CD138 McAb magnetic cell sorting system, and a panel of probes for interphase fluorescence in situ hybridization were used to detect the 13q14 deletion, p53 deletion and IgH gene translocation in the sorted MM cells.</p><p><b>RESULTS</b>Among 23 MM patients, 13q14 deletion was observed in 10 (43.5%) cases, with the positive rate of 13q14 deleted cells ranged from 79% to 96%; 14q32 translocation was observed in 11 (47.8%) cases; 13q14 deletion and 14q32 translocation were simultaneously observed in 7 (30.4%) cases; and p53 deletion was observed in none of the 23 cases.</p><p><b>CONCLUSION</b>The frequency of 13q14 deletion and IgH gene translocation in multiple myeloma are high; and the relationship between 13q14 deletion, IgH gene translocation and prognosis is worth further investigating.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Células Plasmáticas
/
Reordenamiento Génico
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Aberraciones Cromosómicas
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Cadenas Pesadas de Inmunoglobulina
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Hibridación Fluorescente in Situ
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Eliminación de Gen
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Genética
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Mieloma Múltiple
Tipo de estudio:
Prognostic_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Hematology
Año:
2007
Tipo del documento:
Article