Efficacy of Zaozhu Yinchen Recipe for Treating Non-alcoholic Steatohepatitis and its Effect on Free Fatty Acid and TNF-alpha / 中国中西医结合杂志
Zhongguo Zhong Xi Yi Jie He Za Zhi
; (12): 544-548, 2016.
Article
en Zh
| WPRIM
| ID: wpr-328264
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the efficacy of Zaozhu Yinchen Recipe (ZZYCR) on non-alcoholic steatohepatitis (NASH) patients, and to explore its effect on serum free fatty acid (FFA) and tumor necrosis factor alpha (TNF-alpha).</p><p><b>METHODS</b>Totally 120 patients with NASH were randomly assigned to the treatment group (60 cases, treated with ZZYCR, one dose per day) and the control group (60 cases, treated with Silibin Meglumine Tablets, 20 mg each time, thrice per day). The therapeutic course for all was 24 weeks. Serum levels of ALT and AST activities, TC and TG levels were detected before and after treatment. Peritoneal CT was performed in all patients, and CT ratios of liver and spleen calculated. NAFLD activity score (NAS) and degree of hepatic fibrosis were assessed using pathological examinations of liver tissue, and efficacy also evaluated. Serum contents of FFA and TNF-alpha were also detected.</p><p><b>RESULTS</b>Compared with before treatment in the same group, activities of ALT and AST, serum levels of TC, TG, FFA, and TNF-alpha, NAS, scores of symptoms and signs all obviously decreased, degree of hepatic fibrosis was obviously improved in the two groups (P < 0.05, P < 0.01). These changes were more obviously seen in the treatment group (P < 0.05). After 24-week treatment, the total effective rate and total clinical efficacy were 80.00% (48/60 cases) and 85.00% (51/60 cases) in the treatment group, obviously higher than those in the control group [60.00% (36/60 cases) and 73.33% (44/60 cases) respectively], with significant difference (P < 0.05, P < 0.01).</p><p><b>CONCLUSION</b>ZZYCR could improve the clinical efficacy of NASH patients, and its mechanism might be associated with inhibiting serum levels of FFA and TNF-alpha.</p>
Texto completo:
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Base de datos:
WPRIM
Asunto principal:
Sangre
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Medicamentos Herbarios Chinos
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Factor de Necrosis Tumoral alfa
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Usos Terapéuticos
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Quimioterapia
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Ácidos Grasos no Esterificados
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Enfermedad del Hígado Graso no Alcohólico
Límite:
Humans
Idioma:
Zh
Revista:
Zhongguo Zhong Xi Yi Jie He Za Zhi
Año:
2016
Tipo del documento:
Article