Detection of peripheral blood HBV-LHBs transactivation function and its relationship with anti-viral efficacy / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 375-377, 2009.
Article
en Zh
| WPRIM
| ID: wpr-325537
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Explore the serum of patients with CHB of HBV large envelope protein (HBV-LHBs) trans-activation function and antiviral therapy effect relationship.</p><p><b>METHODS</b>60 cases of anti-viral treatment of patients with chronic hepatitis B to take every 3 months HBVDNA, HBV-LHBs, as well as detection of hepatitis B immune markers to observe the changes in indexes.</p><p><b>RESULTS</b>Income group 60 cases of anti-virus group HBVDNA with HBV-LHBs have a higher detection rate of the consistency of the results found no statistical significance (P > 0.05), HBV-LHBs-positive rate and positive rate of HBeAg differences (chi2 = 4.08, P < 0.05). After 24 months of antiviral therapy HBV-LHBs expression always HBVDNA in 29 cases of which occurred 24 months after the negative reaction of the 20 cases, continuous positive were seven cases of non-negative. 60 cases of patients 24 months found no HBsAg seroconversion, four cases of emergence of HBeAg seroconversion.</p><p><b>CONCLUSION</b>(1) detection of serum HBV-LHBs to reflect the hepatitis B virus replication with HBVDNA good correlation. (2) anti-viral treatment of dynamic observation of the process of HBV-LHBs expression can predict the effectiveness of anti-viral therapy.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Antivirales
/
Fisiología
/
Virología
/
Activación Viral
/
Sangre
/
ADN Viral
/
Proteínas del Envoltorio Viral
/
Virus de la Hepatitis B
/
Resultado del Tratamiento
/
Usos Terapéuticos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2009
Tipo del documento:
Article