Selection pressure analysis of H3N2 influenza virus from China between 1992 and 2012 / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 177-180, 2013.
Article
en Zh
| WPRIM
| ID: wpr-318073
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>In order to investigate the relationship between selection pressure and the prevalence of antigenic clusters, we sequenced and analyzed the H3N2 influenza virus from China between 1992 and 2012.</p><p><b>METHODS</b>The H3N2 influenza virus (n = 1206) in China from 1992 to 2012 was analyzed, include global selection pressure and sites positive selection pressure analysis.</p><p><b>RESULTS</b>Considering all the H3N2 influenza viruses during these 21 years, a total of four amino acid sites subject to positive selection. The global selection pressure varies with the variation of different antigenic clusters and three years with peak bottom selection pressure were identified.</p><p><b>CONCLUSION</b>The global selection pressure rise from the peak bottom, a new antigenic clusters will appear andprevalent in the population, indicating the best time to replace the vaccine strain.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Selección Genética
/
Factores de Tiempo
/
Vacunas contra la Influenza
/
China
/
Alergia e Inmunología
/
Subtipo H3N2 del Virus de la Influenza A
/
Genética
/
Antígenos Virales
Tipo de estudio:
Prognostic_studies
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2013
Tipo del documento:
Article