The expression of CD95 and activated antigens in peripheral blood lymphocyte subsets in patients with hand foot and mouth disease (HFMD) / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 33-35, 2010.
Article
en Zh
| WPRIM
| ID: wpr-316974
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of CD95 and special marker for activation of peripheral blood lymphocytes in patients with hand foot and mouth disease (HFMD) and its significance.</p><p><b>METHODS</b>Immunofluorescent two-color flow cytometry was used to study the expression of CD95 and HLA-DR on lymphocytes in 58 patients with HFMD and 34 normal controls.</p><p><b>RESULTS</b>Expression of CD3+ T cells was significantly lower in patients (63.82 +/- 7.74)% than that in controls (P < 0.001), meanwhile the expression of CD4+ T cells was (34.29 +/- 7.33)%, significantly lower than that of the controls (P < 0.005). The percentage of lymphocytes expressing HLA-DR in patients was (23.77 +/- 5.78)%, significantly higher than that of the controls (P < 0.005). Significant difference was observed in the expression of HLA- DR on CD8+ T cells in patients (1.34 +/- 1.12)% as compared with controls (P < 0.005). No significant difference in the expression of CD95 on lymphocytes was observed between patients and the controls (P > 0.05).</p><p><b>CONCLUSION</b>The findings support that cellular immunodeficiency exists in patients and that lymphocytes were abnormally activated in the patients. The activation of peripheral blood T lymphocytes in patients mainly involves CD8 subset and it may play an important role in the immune response to antiviral infection.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Linfocitos T CD4-Positivos
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Estudios de Casos y Controles
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Células Cultivadas
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Subgrupos de Linfocitos T
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Recuento de Linfocitos
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Receptor fas
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Alergia e Inmunología
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Genética
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Enfermedad de Boca, Mano y Pie
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Antígenos
Tipo de estudio:
Observational_studies
Límite:
Child, preschool
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Humans
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Infant
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Male
Idioma:
Zh
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2010
Tipo del documento:
Article