Treatment of an infant with severe neonatal hypoxic-ischemic encephalopathy sequelae with transplantation of human neural stem cells into cerebral ventricle / 中华儿科杂志
Chinese Journal of Pediatrics
; (12): 580-discussion 580, 2005.
Article
en Zh
| WPRIM
| ID: wpr-312116
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Severe newborn hypoxic-ischemic encephalopathy (HIE) has a very high rate of disability and no effective treatment is available. The present study aimed to preliminarily evaluate the effects of human neural stem cell transplantation in treatment of severe neonatal HIE.</p><p><b>METHODS</b>The patient was a 75-day old male infant with sequelae of severe HIE who had highly delayed development of intelligence and movement and myotonia. MRI showed multiple cerebromalacia and encephalatrophy. Cells obtained from the forebrain of an 11-week old fetus were cultured and amplified for 15 days. And then the human fetal neural stem cells were injected into cerebral ventricle of this infant.</p><p><b>RESULTS</b>Twenty eight days after transplantation, remarkable improvement occurred not only in his myotonia but also in his intelligence and movement, which became similar to those of the normal infants of the same age. Positron emission tomography (PET) showed significantly increased radioactivity at temporal and occipital lobes which suggested that the cellular metabolism had increased greatly.</p><p><b>CONCLUSION</b>The short-term effect of NSCs transplantation on the infant with severe HIE sequelae was significant. PET suggested that the implanted NSCs survived. Many more studies are needed to evaluate long-term effects of NSC transplantation in treatment of HIE.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Pronóstico
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Asfixia Neonatal
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Terapéutica
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Factores de Tiempo
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Trasplante
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Encéfalo
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Resultado del Tratamiento
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Hipoxia-Isquemia Encefálica
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Células Madre Multipotentes
Tipo de estudio:
Prognostic_studies
Límite:
Female
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Humans
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Infant
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Newborn
Idioma:
Zh
Revista:
Chinese Journal of Pediatrics
Año:
2005
Tipo del documento:
Article