Relationship between genetic polymorphism of interleukin-6 and pneumoconiosis / 中华劳动卫生职业病杂志
Zhonghua laodong weisheng zhiyebing zazhi
; Zhonghua laodong weisheng zhiyebing zazhi;(12): 534-536, 2006.
Article
en Zh
| WPRIM
| ID: wpr-311413
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between interleukin-6 (IL-6) (-634C/G) genetic polymorphisms and the pneumoconiosis.</p><p><b>METHODS</b>A total of 104 male stage I pneumoconiosis patients diagnosed by the Pneumoconiosis Diagnosis Expert Panel according to the Chinese National Diagnosis Criteria of Pneumoconiosis (GBZ 70 - 2002) were selected. The pneumoconiosis comprised 66 silicosis and 38 coal worker' pneumoconiosis (CWP). A total of 122 workers exposed to same dusts as the patients but without pneumoconiosis including 77 exposed to silica dusts and 45 to coal dusts were selected. The patients and the controls had the same dust exposure history. The peripheral venous blood was drawn from each subject. The IL-6 (-634C/G) genetic polymorphisms were detected by polymerase chain reaction restriction fragment length polymorphisms (PCR-RFLP) techniques.</p><p><b>RESULTS</b>The frequencies of IL-6 (-634C/G) (CC, CG and GG) genotypes were 66.7%, 19.7% and 13.6% in silicosis group, 42.9%, 42.9% and 14.2% in silica dust exposure group, 73.7%, 18.4% and 7.9% in CWP group, 51.1%, 35.6% and 13.3% in coal dust exposure group respectively. The statistical analysis indicated that there was significant difference in the frequencies of IL-6 (-634C/G) (CC, CG and GG) genotypes between silicosis patients and workers exposed to silica dusts (P < 0.05).</p><p><b>CONCLUSION</b>IL-6 (-634 C/G) genetic polymorphisms might play a role in the occurrence of silicosis.</p>
Texto completo:
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Base de datos:
WPRIM
Asunto principal:
Neumoconiosis
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Polimorfismo de Longitud del Fragmento de Restricción
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Estudios de Casos y Controles
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Reacción en Cadena de la Polimerasa
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Interleucina-6
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Análisis por Apareamiento
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Predisposición Genética a la Enfermedad
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Frecuencia de los Genes
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Genética
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Genotipo
Tipo de estudio:
Observational_studies
Límite:
Adult
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Aged
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Aged80
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua laodong weisheng zhiyebing zazhi
Año:
2006
Tipo del documento:
Article