UBE2B gene and male infertility: an update / 中华男科学杂志
National Journal of Andrology
; (12): 367-371, 2014.
Article
en Zh
| WPRIM
| ID: wpr-309704
Biblioteca responsable:
WPRO
ABSTRACT
Male infertility is a worldwide problem, and about 15% of the cases are associated with spermatogenesis-related gene mutation. The mammalian gene UBE2B is the homolog of the RAD6 gene of yeast, belonging to the ubiquitin proteasome system and playing an important role in spermatogenesis. Mice lacking the UBE2B gene are infertile, with reduced sperm motility, increased morphologically abnormal sperm, and inhibited meiosis of spermatogonia. Accumulated evidence shows that UBE2B gene mutants and single nucleotide polymorphisms are associated with male infertility. This article reviews the relation between the UBE2B gene and male infertility, offering some theoretical evidence for the diagnosis and treatment of male infertility.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Espermatogénesis
/
Polimorfismo de Nucleótido Simple
/
Enzimas Ubiquitina-Conjugadoras
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Astenozoospermia
/
Genética
/
Infertilidad Masculina
/
Meiosis
/
Mutación
Límite:
Animals
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Humans
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Male
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2014
Tipo del documento:
Article