Relationship between ERCC2 single nucleotide polymorphisms and male idiopathic infertility in Ningxia / 中华男科学杂志
National Journal of Andrology
; (12): 419-422, 2014.
Article
en Zh
| WPRIM
| ID: wpr-309696
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the influence of the DNA repair gene ERCC2 single nucleotide polymorphisms (SNPs) rs13181, rs1618536, and rs1799793 on male idiopathic infertility in Ningxia, China.</p><p><b>METHODS</b>Using MassArray, we conducted a case-control study and genotyped three ERCC2 SNPs rs13181, rs1618536, and rs1799793 for 351 males (aged 31.0 +/- 4.2 years) with idiopathic infertility and another 327 normal fertile men (aged 33.0 +/- 5.9 years) as controls.</p><p><b>RESULTS</b>The ERCC2 AnyG-anyA-anyA genotypes were significantly associated with an increased risk of idiopathic infertility (OR 0.414, 95% CI 0.176 - 0.970), while the three single ERCC2 SNPs rs13181, rs1618536, and rs1799793 showed no significant differences between the cases and controls (P > 0.05).</p><p><b>CONCLUSION</b>The ERCC2 SNPs rs13181, rs1618536, and rs1799793 play a role of interaction in male idiopathic infertility in Ningxia, contributing to the risk of the disease.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Estudios de Casos y Controles
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China
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Polimorfismo de Nucleótido Simple
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Reparación del ADN
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Proteína de la Xerodermia Pigmentosa del Grupo D
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Genética
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Genotipo
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Infertilidad Masculina
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Adult
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2014
Tipo del documento:
Article