Application of microfluidics in sperm isolation and in vitro fertilization / 中华男科学杂志
National Journal of Andrology
; (12): 452-459, 2014.
Article
en Zh
| WPRIM
| ID: wpr-309689
Biblioteca responsable:
WPRO
ABSTRACT
Due to the low effectiveness of traditional assisted reproductive technology (ART), new technological possibilities are constantly explored. Lots of studies have demonstrated the potential of microfluidics to revolutionize the fundamental processes of in vitro fertilization (IVF). With the advantages of high efficiency, short time, harmless collection, real-time observation of separation, similar microenvironment, and automation, the application of microfluidics in sperm isolation and IVF has shown an evident superiority over the conventional approaches and provided a new platform for ART. This review highlights the application of various microfluidic techniques in sperm motility assessment and isolation, sperm chemotaxis assay, IVF, sperm concentration, and sperm separation and enrichment in recent years. It also briefly introduces the basic principles, structural design, and operation processes of the microfluidic platform, focusing on the advantages and disadvantages of each method and the potential of their clinical application. Obviously, there are still some challenges to the application of microfluidics in ART. However, it is believed that the development of this new technology would be toward a highly integrated application of several steps in one single device, known as IVF-lab-on-a-chip.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Motilidad Espermática
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Espermatozoides
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Técnicas In Vitro
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Fertilización In Vitro
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Técnicas Reproductivas Asistidas
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Microfluídica
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Métodos
Límite:
Humans
/
Male
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2014
Tipo del documento:
Article