Correlation of CD82 and hTERT expressions and HPV infection with penile cancer / 中华男科学杂志
Zhonghua nankexue
; Zhonghua nankexue;(12): 817-822, 2011.
Article
en Zh
| WPRIM
| ID: wpr-305783
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the correlation of the expressions of CD82 and hTERT and HPV infection with the clinical pathological features of penile cancer and identify their prognostic significance in the lymphatic metastasis of the disease.</p><p><b>METHODS</b>A total of 44 patients underwent partial or radical penectomy and lymph node dissection. The expressions of CD82 and hTERT were determined by immunohistochemistry, and HPV infection was detected by PCR.</p><p><b>RESULTS</b>The positive rates of CD82, hTERT, and HPV DNA in penile carcinoma were 47.7%, 38.6% and 25.9%, respectively. The amplified HPV DNA was HPV-16. The pathological stage and hTERT expression were positively correlated with inguinal lymph node metastasis of penile cancer (P = 0.032, P = 0.041), and so was the pathological stage with the expression of CD82 (P = 0.045), but neither the pathological stage, nor the expression of CD82 or the positive rate of HPV DNA showed any correlation with lymph node metastasis (P = 0.627, P = 0.094, P = 0.633).</p><p><b>CONCLUSION</b>The pathological grade and hTERT expression are independent prognostic factors for lymph node metastasis in penile carcinoma. These features help the prognosis and identification of the patient at the risk of nodal metastasis.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Papillomaviridae
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Patología
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Neoplasias del Pene
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Virología
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Carcinoma de Células Escamosas
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Telomerasa
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Infecciones por Papillomavirus
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Proteína Kangai-1
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Metabolismo
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Estadificación de Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Aged80
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua nankexue
Año:
2011
Tipo del documento:
Article