FSH and FSHR gene polymorphisms and male infertility: An update / 中华男科学杂志
Zhonghua nankexue
; Zhonghua nankexue;(12): 1031-1034, 2015.
Article
en Zh
| WPRIM
| ID: wpr-304776
Biblioteca responsable:
WPRO
ABSTRACT
Follicle-stimulating hormone (FSH) is synthesized and secreted by the anterior pituitary, which binds to its receptors expressed on the membrane of Sertoli cells in the testis to bring about spermatogenesis. With the development of DNA sequencing technology, FSH SNPs rs10835638 and FSHR SNPs rs6165, rs6166, and rs1394205 were detected, which might directly affect the expression of FSH and activity of FSHR, resulting in male spermatogenic dysfunction. This review focuses on the relationship of FSH and FSHR gene polymorphisms with male infertility.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Células de Sertoli
/
Espermatogénesis
/
Testículo
/
Receptores de HFE
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Polimorfismo de Nucleótido Simple
/
Hormona Folículo Estimulante
/
Genética
/
Infertilidad Masculina
Límite:
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua nankexue
Año:
2015
Tipo del documento:
Article