Clinical analysis of liver transplantation for autoimmune hepatitis / 中华肝脏病杂志
Zhonghua ganzangbing zazhi
; Zhonghua ganzangbing zazhi;(12): 860-864, 2015.
Article
en Zh
| WPRIM
| ID: wpr-303217
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To describe the outcomes and recurrence of autoimmune hepatitis (AIH) after liver transplantation.</p><p><b>METHODS</b>Clinical data of 16 patients with AIH who underwent liver transplantation were analyzed retrospectively. The postoperative cumulative survival rate of the patients was calculated. The postoperative rejections and AIH recurrence were analyzed. The Kaplan-Meier method was used for statistical analysis of survival.</p><p><b>RESULTS</b>All patients were female, with an average age of 52.6 years (range: 41-66 years), and an average MELD score of 21.4. According serological analysis, 15 patients were AIH type 1 and 1 patient was AIH type 2. Three patients died, including 2 of pulmonary infection and 1 of graft dysfunction.The 1-, 2-and 5-year cumulative survival rates were 93.8%, 87.1% and 79.1%, respectively. Five cases (31.3%) of recurrent AIH were diagnosed based on histological evidence. Acute rejection occurred in 6 (37.5%) patients, and de novo HBV infection occurred in 1 (6.3%) patient.</p><p><b>CONCLUSION</b>Liver transplantation is an effective treatment for end-stage AIH. Recurrence and rejection were commonly associated with AIH, but did not negatively impact patient survival.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Periodo Posoperatorio
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Recurrencia
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Cirugía General
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Tasa de Supervivencia
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Estudios Retrospectivos
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Trasplante de Hígado
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Resultado del Tratamiento
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Hepatitis Autoinmune
Tipo de estudio:
Observational_studies
Límite:
Adult
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Aged
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Female
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Humans
Idioma:
Zh
Revista:
Zhonghua ganzangbing zazhi
Año:
2015
Tipo del documento:
Article