Comparison of efficacy and adverse effects between arsenic trioxide and all-trans retinoic acid in patients with acute promyelocytic leukemia / 中国医学科学院学报
Zhongguo yi xue ke xue yuan xue bao
; Zhongguo yi xue ke xue yuan xue bao;(6): 555-558, 2009.
Article
en Zh
| WPRIM
| ID: wpr-301653
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the efficacy and adverse effects between arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) in patients with acute promyelocytic leukemia (APL).</p><p><b>METHODS</b>The clinical data of 71 patients with newly diagnosed APL were retrospectively analyzed. Two groups were classified according to the induction regimens, namely ATO group (n = 41) and ATRA group (n = 30). The complete remission (CR) rate and the time to CR were compared between these two groups.</p><p><b>RESULTS</b>The CR rate was 97.5% in ATO group and 93.3% in ATRA group (P > 0.05). The median time to CR was 29 days (21-45 days) in ATO group, which was significantly shorter than 38.5 days (24-63 days) in ATRA group (P < 0.001). Retinoic acid syndrome occurred in 52.9% of patients treated with ATRA, which affected the further use of ATRA.</p><p><b>CONCLUSIONS</b>Both ATO and ATRA have high response rates for newly diagnosed patients with APL. Compared with ATRA, ATO induction therapy has shorter time to achieve CR and less adverse effects, and therefore may be the first-line therapy for APL.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Óxidos
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Arsenicales
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Tretinoina
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Inducción de Remisión
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Leucemia Promielocítica Aguda
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Estudios Retrospectivos
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Resultado del Tratamiento
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Usos Terapéuticos
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Quimioterapia
Tipo de estudio:
Observational_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhongguo yi xue ke xue yuan xue bao
Año:
2009
Tipo del documento:
Article