Effect of c-kit mutation on the prognosis of gastrointestinal stromal tumors: a meta-analysis / 中华外科杂志
Chinese Journal of Surgery
; (12): 857-862, 2009.
Article
en Zh
| WPRIM
| ID: wpr-299722
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of c-kit mutation on the prognosis of gastrointestinal stromal tumors.</p><p><b>METHODS</b>A search of studies in PubMed and MedLine (from 1999 to 2008) was performed to assess the effect of c-kit mutation on the prognosis of gastrointestinal stromal tumors. The articles were retrieved with the entries of "gastrointestinal stromal tumors", "imatinib", "c-kit" and "mutation". A meta-analysis was performed to assess the data included.</p><p><b>RESULTS</b>A total of 15 articles were collected in this analysis. No significant differences was found in incidence of mitoses (> 5/50 HPF) between the patients with wild type c-kit (wild type group) and the ones with mutated c-kit (mutation group) (P = 0.710); tumor recurrence and metastasis rate after surgery was significant higher in the mutation group than that in wild type group (P = 0.010); as for imatinib response with different c-kit mutation types, the results showed the incidence of clinical response (complete response + partial response) was significantly higher in mutation group than that in wild type group (P = 0.009), but the imatinib resistance rate was lower in mutation group (P = 0.000); three studies provided data for imatinib resistance with c-kit second mutations, the results showed the second mutations mainly focus on exon 13, 14, 17.</p><p><b>CONCLUSIONS</b>C-kit mutation is related closely with the incidence of recurrence and metastasis in GIST after surgery. The mutations of c-kit influences the therapeutic effects of imatinib.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Piperazinas
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Pronóstico
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Pirimidinas
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Benzamidas
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Estudios de Casos y Controles
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Proteínas Proto-Oncogénicas c-kit
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Usos Terapéuticos
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Tumores del Estroma Gastrointestinal
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Quimioterapia
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Mesilato de Imatinib
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Surgery
Año:
2009
Tipo del documento:
Article