Expressions and significance of STAT3 and p38 in the carcinogenesis of sporadic colorectal tubular adenoma / 中华肿瘤杂志
Zhonghua zhong liu za zhi
; (12): 514-517, 2007.
Article
en Zh
| WPRIM
| ID: wpr-298562
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the possible role of STAT3 and p38 in the carcinogenesis of sporadic colorectal tubular adenoma.</p><p><b>METHODS</b>The expression of STAT3 and p38 at protein level was studied in 107 sporadic colorectal tubular adenomas with different dysplasia (SCTA-D) or with cancerous changes (SCTA-Ca) by immunohistochemical staining method, meanwhile the expression of STAT3 at mRNA level was detected by in situ hybridization.</p><p><b>RESULTS</b>Immunohistochemical staining results showed that the positive expression rate of STAT3 and p38 was 12.0%, 59.0%, 91.7% and 8.0%, 47.0%, 91.7% in normal colorectal mucosa (NCM), SCTA-D and SCTA-Ca, respectively, with a statistically significant difference of STAT3 and p38 expression among the SCTA-D, SCTA-Ca and NCM (P < 0.05). The expression of STAT3 and p38 was positively correlated with the degree of dysplasia from mild to severe SCTA-D (P < 0.05). In situ hybridization results showed that the positive expression rate of STAT3 at mRNA level in NCM, SCTA-D and SCTA-Ca was 8.00%, 51.8% and 100.0%, respectively, with a statistically significant difference among these either (P < 0.05). The positive expression of STAT3 at mRNA level was not only positively correlated with the degree of dysplasia (P < 0.05), but also with the expression of p38 (P < 0.05).</p><p><b>CONCLUSION</b>STAT3 and p38 may be involved in the carcinogenesis of sporadic colorectal tubular adenoma.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Lesiones Precancerosas
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ARN Mensajero
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Neoplasias Colorrectales
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Adenocarcinoma
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Adenoma
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Regulación Neoplásica de la Expresión Génica
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Transformación Celular Neoplásica
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Proteínas Quinasas p38 Activadas por Mitógenos
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Factor de Transcripción STAT3
Límite:
Humans
Idioma:
Zh
Revista:
Zhonghua zhong liu za zhi
Año:
2007
Tipo del documento:
Article