Effect of simian vacuolating virus 40 on development and differentiation of dendritic cells from Rhesus macaque / 病毒学报
Chinese Journal of Virology
; (6): 344-348, 2009.
Article
en Zh
| WPRIM
| ID: wpr-297950
Biblioteca responsable:
WPRO
ABSTRACT
To study the effect of simian vacuolating virus 40 (SV40) on development and differentiation of dendritic cells (DC) from rhesus macaque, the peripheral blood-derived dendritic cells from rhesus monkey were pulsed with inactivated SV40 and infective SV40, respectively at the 5th day post DC cultivation. Expressions of CD1a, HLA-DR, CD86 and CD83 on the cell surface at the 7th, 9th day post DC cultivation were analyzed by flow cytometry (FCM). The results showed that expressions of CD1a, HLA-DR, CD86 and CD83 on the cell surface in the inactivated SV40-pulsed experimental group were higher than those in the infective SV40-pulsed experimental group (P < 0.05). These cell surface molecules represented characteristic development and differentiation phase of DC. Down-regulation of expressions of these cell surface molecules indicated that infective SV40 might hamper differentiation and maturation of dendritic cells from rhesus monkey.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fisiología
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Virología
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Células Dendríticas
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Inmunoglobulinas
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Glicoproteínas de Membrana
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Antígenos HLA-DR
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Antígenos CD
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Diferenciación Celular
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Células Cultivadas
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Virus 40 de los Simios
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Virology
Año:
2009
Tipo del documento:
Article