Advances in rapid prenatal detection of fetal chromosome abnormalities / 中华男科学杂志
Zhonghua nankexue
; Zhonghua nankexue;(12): 359-363, 2010.
Article
en Zh
| WPRIM
| ID: wpr-295058
Biblioteca responsable:
WPRO
ABSTRACT
Rapid prenatal detection methods, including molecular cytogenetic analysis and ultrasonographic markers, are very important for prenatal diagnosis. The use of molecular cytogenetic techniques has significantly improved the rapid detection of aneuploidy and identification of small structural abnormalities of fetal chromosomes. At present, commonly used molecular cytogenetic techniques include fluorescence in situ hybridization (FISH), quantitative fluorescence PCR (QF-PCR), multiplex ligation-dependent probe amplification (MLPA) and microarray-based comparative genomic hybridization (array CGH). There is extensive evidence that major chromosomal abnormalities can be effectively detected by ultrasonography in the first and second trimesters of pregnancy. So we can combine molecular cytogenetic techniques with ultrasonographic markers to improve the identification of aneuploidies for chromosomes and the accuracy of prenatal diagnosis, and to reduce birth defects in newborns.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Diagnóstico Prenatal
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Reacción en Cadena de la Polimerasa
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Ultrasonografía Prenatal
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Aberraciones Cromosómicas
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Hibridación Fluorescente in Situ
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Trastornos de los Cromosomas
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Análisis Citogenético
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Análisis por Matrices de Proteínas
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Diagnóstico
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Microanálisis por Sonda Electrónica
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
Zh
Revista:
Zhonghua nankexue
Año:
2010
Tipo del documento:
Article