Role of ABC transporters in cancer chemotherapy / 癌症
Chinese Journal of Cancer
; (12): 51-57, 2012.
Article
en En
| WPRIM
| ID: wpr-294431
Biblioteca responsable:
WPRO
ABSTRACT
Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality. The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette (ABC) transporters, which can increase efflux of drugs from cancer cells, thereby decreasing intracellular drug concentration. Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Proteínas Tirosina Quinasas
/
Miembro 1 de la Subfamilia B de Casetes de Unión a ATP
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Resistencia a Múltiples Medicamentos
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Transportadoras de Casetes de Unión a ATP
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Resistencia a Antineoplásicos
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Proteínas Asociadas a Resistencia a Múltiples Medicamentos
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Usos Terapéuticos
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Quimioterapia
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Nanomedicina
/
Terapia Molecular Dirigida
Límite:
Humans
Idioma:
En
Revista:
Chinese Journal of Cancer
Año:
2012
Tipo del documento:
Article