Effect of intervention of granules of eliminating phlegm and removing blood stasis in cochlear morphology of diabetic rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 209-215, 2011.
Article
en Zh
| WPRIM
| ID: wpr-289397
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effectiveness of the granules of eliminating phlegm and removing blood stasis (GEPRB) on glucose metabolism for diabetic rats induced by streptozotocin and that on early diabetic rats cochlear histopathology.</p><p><b>METHOD</b>Intraperitoneally inject streptozotocin disposable of dose of 55 mg x kg(-1), so that a model of diabetic rats is created, and treated by, and simultaneously treated by Duxil as matched groups for positive, then observe the blood glucose of each group, the histopathology of cochlear, and any circumstantial change of their microstructures.</p><p><b>RESULT</b>GEPRB can reduce the cumulating thickness of the basilar membrane and that of the vascular pattern, so as to tighten up the sparsity of the spiral ganglion cells.</p><p><b>CONCLUSION</b>GEPRB is rather effective on hypoglycemic for the diabetic rat model, and therapeutic goal can be achieved by improving the pathological changes of the cochlea damaged. The improvement by GEPRB for microangiopathic change of the cochlea capillary is probably the pathological basis of relieving hearing loss.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Medicamentos Herbarios Chinos
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Ratas Sprague-Dawley
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Cóclea
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Complicaciones de la Diabetes
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Modelos Animales de Enfermedad
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Formas de Dosificación
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Quimioterapia
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Enfermedades del Oído
Límite:
Animals
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Humans
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Male
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2011
Tipo del documento:
Article