Exposure to 1-bromopropane causes dose-dependent neurological abnormalities in workers / 中华劳动卫生职业病杂志
Zhonghua laodong weisheng zhiyebing zazhi
; Zhonghua laodong weisheng zhiyebing zazhi;(12): 488-493, 2010.
Article
en Zh
| WPRIM
| ID: wpr-288376
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the dose-effect relationship between 1-bromopropane (1-BP) exposure and health effects in workers.</p><p><b>METHODS</b>Occupational field investigations were conducted in 1-BP factories. Ambient 1-BP concentrations were detected with detection tube, and the 8 h time-weighted average individual exposure levels (TWA-8 h) were measured by passive sampler. Workers underwent questionnaire survey, neurological examination, nerve conduction velocity examination, vibration sensation test. routine blood test as well as blood biochemical test. According to TWA values or TWA x duration values, workers were divided into three dose groups for dose-effect relationship analysis. USEPA BMDS 2.1 software was applied to calculate 1-BP benchmark dose (BMD) and its 95% lower limit (BMDL).</p><p><b>RESULTS</b>The TWA-8h concentrations ranged from 0.35 to 535.19 mg/m3 (geo-mean 14.08 mg/m3). Dose-dependent analysis showed that the motor nerve distal latency (linear regression coefficient was 0.066 6), vibration sensation of toes (linear regression coefficient were 0.157 2 and 0.193 9), creatine kinase (linear regression coefficient was -1.05) and thyroid stimulating hormone levels (linear regression coefficient was 0.1024) of 1-BP exposed workers changed in a dose-dependent manner (P < 0.05). BMD calculation based on DL as 1-BP toxic effect endpoint showed that TWA-8h of the BMD values and BMDL values were 50.55 mg/m3 and 30.78 mg/m3, respectively.</p><p><b>CONCLUSION</b>1-BP causes dose-dependent changes in tibial nerve DL, vibration sensation, CK and TSH levels.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Nervio Tibial
/
Sangre
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Exposición Profesional
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Lugar de Trabajo
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Creatina Quinasa
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Dosis Máxima Tolerada
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Toxicidad
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Hidrocarburos Bromados
/
Conducción Nerviosa
Tipo de estudio:
Etiology_studies
Límite:
Adult
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Female
/
Humans
Idioma:
Zh
Revista:
Zhonghua laodong weisheng zhiyebing zazhi
Año:
2010
Tipo del documento:
Article