The investigation of the relationship between the phenotypes of 46, XX males and the SRY gene / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 95-97, 2009.
Article
en Zh
| WPRIM
| ID: wpr-287445
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the phenotypes in XX male patients and the sex determining region(SRY) gene.</p><p><b>METHODS</b>Multiple polymerase chain reactions were carried out in 6 male patients with karyotype of 46, XX, and then the PCR products were sequenced directly.</p><p><b>RESULTS</b>Three cases of male infertility were positive for the SRY gene without evident malformation in their extra genitalia, while 3 cases with testes were negative for the SRY gene, with evident malformation in their extra genitalia.</p><p><b>CONCLUSION</b>The SRY gene is key in sex determination and development, yet there might be other important genes involved.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Fenotipo
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Aberraciones Cromosómicas Sexuales
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Reacción en Cadena de la Polimerasa
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Análisis de Secuencia de ADN
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Trastornos de los Cromosomas Sexuales
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Genes sry
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Genética
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Genitales Masculinos
Límite:
Adult
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Child, preschool
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Humans
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Infant
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Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2009
Tipo del documento:
Article