Caveolin-1: a novel biomarker for prostate cancer / 中华男科学杂志
National Journal of Andrology
; (12): 635-638, 2012.
Article
en Zh
| WPRIM
| ID: wpr-286431
Biblioteca responsable:
WPRO
ABSTRACT
For lack of the biomarker, early diagnosis of prostate cancer is often difficult. Caveolin-1 (Cav-1) is an important oncogene and a major structural coat protein of caveolae, which is involved in multiple cellular functions including molecular transport, cell adhesion, and signal transduction, as well as in the development and progression of prostate cancer. Cav-1 is secreted as a biologically active molecule that promotes cell survival and angiogenesis within the tumor microenvironment, and is overexpressed in the metastatic and primary sites of human prostate cancer. Secreted Cav-1 can be detected in the peripheral blood, and its expression level has an indicative value in the diagnosis and prognosis of prostate cancer. This review focuses on the structure and biological characteristics of Cav-1 and its correlation with prostate cancer.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neoplasias de la Próstata
/
Biomarcadores de Tumor
/
Diagnóstico
/
Caveolina 1
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Límite:
Humans
/
Male
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2012
Tipo del documento:
Article