Prognostic analysis of curative surgery for stage IIIA-N2 non-small cell lung cancer / 中华肿瘤杂志
Zhonghua zhong liu za zhi
; (12): 50-53, 2013.
Article
en Zh
| WPRIM
| ID: wpr-284240
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the survival and prognostic factors in patients undergoing potentially curative resection of stage IIIA-N2 non-small cell lung cancer.</p><p><b>METHODS</b>Clinical data of eighty-nine patients, who underwent curative operation from January 2003 to April 2007 in the Peking University First Hospital and were pathologically diagnosed as stage IIIA-N2 NSCLC, were reviewed. The patients were followed up until death or the cut-off date. The overall 3-year and 5-year survival rates were calculated, and Cox proportional hazard model was used to determine the clinical and pathological risk factors and evaluate their influence on the survival.</p><p><b>RESULTS</b>The three-year and five-year survival rates were 51.7% and 31.5%, respectively. The univariate Cox regression analysis revealed five significant factors associated with prognosis: the arm of age < 55, T3 stage, lymphovascular invasion (LVI), multiple positive N2 station and the number of positive N2 nodes > 3 were found to be at increased risk of tumor-related death, and those risk factors were confirmed especially in the age ≥ 55 group. Multivariate Cox regression analysis indicated three independent prognostic factors: T3 stage, LVI and multiple positive N2 station.</p><p><b>CONCLUSIONS</b>The results of this preliminary study show that T3 stage, lymphovascular invasion and N2 level (single or multiple station) are associated with the prognosis of stage IIIA-N2 NSCLC patients after potentially curative resection, and the characteristics of age < 55 and the number of positive N2 nodes > 3 may imply worse prognosis.</p>
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Base de datos:
WPRIM
Asunto principal:
Patología
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Neumonectomía
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Cirugía General
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Protocolos de Quimioterapia Combinada Antineoplásica
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Modelos de Riesgos Proporcionales
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Tasa de Supervivencia
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Estudios Retrospectivos
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Estudios de Seguimiento
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Carboplatino
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Factores de Edad
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua zhong liu za zhi
Año:
2013
Tipo del documento:
Article