Expression of Ezrin in gastric carcinoma and its significance / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 433-435, 2006.
Article
en Zh
| WPRIM
| ID: wpr-283302
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of Ezrin in gastric cancer, its role in tumor metastasis.</p><p><b>METHODS</b>Ezrin expression in tumor tissues from 90 gastric cancer cases and in normal gastric mucosa from 12 cases with benign disease was examined by immunohistochemical staining. Ezrin expression in gastric cancer cell lines was also detected by Western blot, and in vitro invasion assay was used to examine the invasive ability of the cell lines.</p><p><b>RESULTS</b>The expression rate of Ezrin was significantly higher in gastric cancer tissues than that in normal tissues (P< 0.05), and significantly correlated with lymph node metastasis (P< 0.05). Western blot showed that MKN-45 cell line had the highest expression of Ezrin among 5 gastric cancer cells. MKN-45 possessed highest invasion ability.</p><p><b>CONCLUSION</b>Ezrin expression is up-regulated, and may be associated with lymph node metastasis in gastric cancer.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Neoplasias Gástricas
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Expresión Génica
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Proteínas del Citoesqueleto
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Análisis por Matrices de Proteínas
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Línea Celular Tumoral
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Genética
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Metástasis Linfática
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Metabolismo
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Invasividad Neoplásica
Límite:
Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Gastrointestinal Surgery
Año:
2006
Tipo del documento:
Article