Expression of B7-H1 on peripheral blood mononuclear cells from chronic hepatitis B patients / 南方医科大学学报
Journal of Southern Medical University
; (12): 1635-1637, 2007.
Article
en Zh
| WPRIM
| ID: wpr-283069
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of B7-H1 on peripheral blood mononuclear cells from patients with chronic HBV infection.</p><p><b>METHODS</b>Immunofluorescent staining and flow cytometry assay were used to measure the expression of B7-H1 on peripheral blood CD3high T cells, CD19high B cells and CD14high monocytes from chronic HBV infected patients.</p><p><b>RESULTS</b>No significant difference was observed in B7-H1 expression on T cells and B cells between chronic HBV infected patients (CHB) and health controls (HC). B7-H1-expressing CD14high cells were significantly increased in chronic HBV-infected patients (19.17-/+11.64)% as compared with healthy controls [(7.30-/+5.49)%, P<0.01]. A significant positive correlation was found between B7-H1 expression on CD14high monocytes and serum ALT levels.</p><p><b>CONCLUSION</b>There is no significant difference in B7-H1 expression on T cells and B cells between CHB patients and healthy subjects. B7-H1, which is up-regulated on monocytes from chronic HBV-infected patients, in positively correlated to serum ALT levels, and may play a role in the persistence of HBV infection.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Leucocitos Mononucleares
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Linfocitos B
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Monocitos
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Linfocitos T
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Antígenos CD
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Estudios de Casos y Controles
/
Hepatitis B Crónica
/
Alergia e Inmunología
/
Antígeno B7-H1
/
Metabolismo
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2007
Tipo del documento:
Article