Permeabilities of rebamipide via different intestinal mucosa in the diffusion chamber in vitro / 药学学报
Acta Pharmaceutica Sinica
; (12): 314-317, 2008.
Article
en Zh
| WPRIM
| ID: wpr-277855
Biblioteca responsable:
WPRO
ABSTRACT
The objective of this study is to investigate the permeabilities of rebamipide across the jejunal, ileal and colonic membranes in rat. The permeability (Papp) of rebamipide via rat intestinal membranes at concentration of 80 micromol L(-1) was evaluated by an in vitro diffusion chamber system after the membranes were isolated from the rat intestine. And the concentration of rebamipide in the receptor was determined by HPLC. As a result, the permeability of rebamipide across the jejunal or ileal membrane was higher than that across the colonic membrane, and the permeability of rebamipide in the ileal tissue from the serosal to mucosal direction was greater than that from the mucosal to serosal direction. Therefore, there was a regional difference in the permeability of rabamipide across the jejunum, ileum and the colon in rat. Also, the transporters in the intestinal mucosa as p-glycoprotein may not be involved in the transport of rebamipide.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Permeabilidad
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Transporte Biológico
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Farmacocinética
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Permeabilidad de la Membrana Celular
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Ratas Wistar
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Colon
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Quinolonas
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Biología Celular
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Alanina
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Íleon
Límite:
Animals
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2008
Tipo del documento:
Article