Studies on anti-hyperglycemic effect and its mechanism of Dendrobium candidum / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 160-163, 2004.
Article
en Zh
| WPRIM
| ID: wpr-276590
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the anti-hyperglycemic effect and its mechanism of Dendrobium candidum (DC).</p><p><b>METHOD</b>Normal mice, adrenaline-induced hyperglycemic mice, streptozotocin-induced diabetic (STZ-DM) rats were used. The mechanisms of the anti-hyperglycemic action were studied with radio-immunoassay, immunohistochemical HRP-SPA stain, etc.</p><p><b>RESULT</b>DC could not obviously decrease the serum glucose concentrations and insulin levels in normal mice. It could increase serum insulin levels and decrease serum glucagons concentrations in STZ-DM rats. The results of immunohistochemical stain demonstrated that the number of islet beta cells was increased and that of islet a cells was decreased in STZ-DM rats. It could also decrease the serum glucose concentrations and increase liver glucogen contents in adrenaline-induced hyperglycemic mice.</p><p><b>CONCLUSION</b>DC has obvious anti-hyperglycemic effects in adrenaline-induced hyperglycemic mice and STZ-DM rats. Its mechanisms are stimulating the secretion of insulin from beta cells and inhibiting the secretion of glucagons from a cells, and it can probably decrease the decomposition of liver glucogen and increase the synthesis of liver glucogen.</p>
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Base de datos:
WPRIM
Asunto principal:
Patología
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Farmacología
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Plantas Medicinales
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Sangre
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Glucemia
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Glucagón
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Medicamentos Herbarios Chinos
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Epinefrina
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Química
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Islotes Pancreáticos
Límite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2004
Tipo del documento:
Article